THE ASSOCIATION OF IMMUNE RESPONSE TO XENOAND ENDOBIOTIKS AND THEIRS BIOTRANSFORMATION ENZYME GENE POLYMORPHISM WITH CONGENITAL MALFORMATIONS OF THE FETUS

Abstract

The correlation between immune response to benzo(a)pyrene and progesterone in combination with detoxification enzyme gene polymorphism (CYPIA2*1F and GSTTI) and the occurrence of congenital malformations of the fetus was revealed. It is shown that at high ratio of IgA-antibodies to benzo(a)pyrene and to progesterone in conjunction with the mutant allele of the gene CYPIA2*1F and the deletion genotype of the gene GSTTI chance of the reproductive pathology developing increases to 41 times.

Keywords

• antibodies to benzo(a)pyrene
• a genetic polymorphism
• congenital fetal malformations