Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis

Abstract

Highlights Adiponectin (ADIPOQ) plays an important role in the development of type 2 diabetes and previous studies regarding the association between ADIPOQ polymorphisms and T2D risk reported conflicting results. We performed a meta-analysis to assess the association between two ADIPOQ polymorphisms [− 11377C/G (rs266729), and +276G/T (rs1501299)] and risk for T2D. Odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs) were pooled to assess the association between four aforementioned polymorphisms and susceptibility to T2D. Overall, there was an association between ADIPOQ +276 G > T with increased T2D risk. Subgroup by ethnicity suggested significant association between +276G/T polymorphism and T2D risk among European ethnicities. Our findings evidence a positive association between ADIPOQ +276 G > T polymorphism with increased risk of T2D in male individuals with European ethnicity.

Keywords

• Adiponectin
• Type 2 diabetes
• SNP − 11377
• SNP + 276
• Single nucleotide polymorphism