Determination of the activity of drug-metabolizing enzymes - the prospects for their use in clinical practice

Abstract

One of the common issues of modern medicine is the risk of adverse drug effects when administering certain medicines. The causes of these effects may be various, but they mostly occur because of increased or decreased activity of xenobiotic-metabolizing enzymes, based on cytochrome P450 isoenzyme system (also known as CYP). For the date there is a number of different ways to determine the activity of the mentioned system in specific patient. The authors have studied the basic methods of determining the activity of drug-metabolizing enzymes and the approaches to their introduction into clinical practice, as well as the prospects of using them for the purpose of personalization of pharmacy and pharmacotherapy rationalization.

Keywords

• цитохром p450
• cyp
• фенотипирование
• персонализированная медицина
• фармакотерапия
• cytochrome p450
• cyp
• phenotyping
• personalized therapy
• pharmacotherapy