Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān (Jul 2020)

Relationship between level of vitamins and Hydatiform Mole in Women: A Systematic Review Study

  • Mojdeh Banaei,
  • Seyedeh Hanieh Alamolhoda,
  • Maryam Beheshti Nasab,
  • Leila Mohamadkhani Shahri,
  • Fatemeh Bayat

DOI
https://doi.org/10.22038/ijogi.2020.16619
Journal volume & issue
Vol. 23, no. 5
pp. 95 – 104

Abstract

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Introduction: Hydatidiform mole is one of the emergency risks in pregnancy that can threaten the life of women of childbearing age with risk of death. Various studies have reported different risk factors for this disease. One of these factors is nutritional deficiency, especially vitamin deficiencies, which can lead to this condition. Therefore, this study was performed with aim to systematic review of the relationship between the blood level of vitamins in women and hydatidiform mole. Methods: In this systematic review study, for finding the related articles, the international databases such as: Web of Science, Scopus, PubMed and Embase, Google Scholar and national databases such as: MagIran, SID, IranDoc and IranMedex were evaluated using the keywords of: "Hydatidiform Mole", "Gestational Trophoblastic Disease", "Molar Pregnancy" and "Vitamin" which were combined with the OR and AND Boolean operators without time limitation. Finally, two researchers independently reviewed the articles for assessment of the quality (by using NOS checklist) and data extraction. Results: Finally, 10 articles were included with total sample size of 1134 women. The publication¢s year of papers was from 1988 to 2018 and all studies were case-control. The findings showed that level of vitamins A, D, E, C, B9 and B12 are associated with hydatidiform mole, so that decreasing of these vitamins leads to molar pregnancy. In most of the studies, there was decreased level of these vitamins in both complete and incomplete molar pregnancy. Conclusion: Decreased level of vitamins A, D, E, C, B9 and B12 can increase the risk of molar pregnancy. Therefore, by examining and determining the nutritional deficiencies in women with history of molar pregnancy, we can evaluate the effect and administration of vitamin supplements on recurrence of hydatidiform mole can by designing clinical trials.

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