Nature Communications (Nov 2022)
Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition
Abstract
Drg1 is a cytoplasmic AAA + ATPase responsible for releasing Rlp24 during ribosome assembly. Here, the authors show that Drg1 structurally and functionally shares many regulatory features with that of Cdc48/p97, suggesting a unfoldase role for Drg1.