Nature Communications (Nov 2022)

Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition

  • Chengying Ma,
  • Damu Wu,
  • Qian Chen,
  • Ning Gao

DOI
https://doi.org/10.1038/s41467-022-34511-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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Drg1 is a cytoplasmic AAA + ATPase responsible for releasing Rlp24 during ribosome assembly. Here, the authors show that Drg1 structurally and functionally shares many regulatory features with that of Cdc48/p97, suggesting a unfoldase role for Drg1.