Synthesis , characterization of some formazane derivatives and study their dyes stability and antibacterial activity

Abstract

This research Includes the synthesis of some formazan derivatives from reaction of terephthaldehyd with Phenyl hydrazine through hydrazones (1) and ended with formazan derivatives as follows: Synthesis of hydrazon through reaction of terephthaldehyd with Phenyl hydrazine compounds (1). Convert hydrazon compound number (1) to the formazan derivatives through reaction with diazonium salts the compounds (2-14). Stability of pigments synthesis compounds was measured of (2-14) by using wool, cotton, paper and sawdust have shown that, these compounds (pigments) have good stability against washing with water and then use a bleaching solution . The synthesized compounds have been characterized by Ultraviolet (UV) , Infrared spectrum (FT-IR) , Nuclear Magnetic Resonance (1H-NMR) , ( C.H.N) analysis of the elements for some compounds and by their melting point and checked through T.L.C. Study the dyes stability and antibacterial activity of some of the synthesized compounds against Gram positive bacteria (Staphylococcus aureus , Streptococcus pyogenes) and Gram negative bacteria( Escherichia Coli and Pseudomonas aeruginosa )and they were found to exhibit good to moderate antibacterial activity.

Keywords

• hydrazine
• formazane
• diazonium salts
• antibacterial activity