Unipolar Peptidoglycan Synthesis in the
<i>Rhizobiales</i>
Requires an Essential Class A Penicillin-Binding Protein
Michelle A. Williams,
Alena Aliashkevich,
Elizaveta Krol,
Erkin Kuru,
Jacob M. Bouchier,
Jonathan Rittichier,
Yves V. Brun,
Michael S. VanNieuwenhze,
Anke Becker,
Felipe Cava,
Pamela J. B. Brown
Affiliations
Michelle A. Williams
Division of Biological Sciences, University of Missouri, Columbia, Missouri, USA
Alena Aliashkevich
Department of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden (MIMS), Centre for Microbial Research, Umeå University, Umeå, Sweden
Elizaveta Krol
Center for Synthetic Microbiology (SYNMIKRO), Philipps University Marburg, Marburg, Germany
Erkin Kuru
Department of Chemistry, Indiana University, Bloomington, Indiana, USA
Jacob M. Bouchier
Division of Biological Sciences, University of Missouri, Columbia, Missouri, USA
Jonathan Rittichier
Department of Chemistry, Indiana University, Bloomington, Indiana, USA
Yves V. Brun
Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada
Michael S. VanNieuwenhze
Department of Chemistry, Indiana University, Bloomington, Indiana, USA
Anke Becker
Center for Synthetic Microbiology (SYNMIKRO), Philipps University Marburg, Marburg, Germany
Department of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden (MIMS), Centre for Microbial Research, Umeå University, Umeå, Sweden
While the structure and function of the bacterial cell wall are well conserved, the mechanisms responsible for cell wall biosynthesis during elongation are variable. It is increasingly clear that rod-shaped bacteria use a diverse array of growth strategies with distinct spatial zones of cell wall biosynthesis, including lateral elongation, unipolar growth, bipolar elongation, and medial elongation.
