A Novel SEC22B-NOTCH2 Fusion in Chronic Lymphocytic Leukemia

Rory Crotty; Dora Dias-Santagata; Jon C. Aster; Valentina Nardi

doi:10.1016/j.ehpc.2020.200408

Human Pathology: Case Reports (Sep 2020)

A Novel SEC22B-NOTCH2 Fusion in Chronic Lymphocytic Leukemia

Rory Crotty,
Dora Dias-Santagata,
Jon C. Aster,
Valentina Nardi

Affiliations

Rory Crotty: Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States; Corresponding author at: Massachusetts General Hospital and Harvard Medical School, Department of Pathology, Warren Building 225, 55 Fruit Street, Boston, MA 02114, United States.
Dora Dias-Santagata: Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
Jon C. Aster: Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States
Valentina Nardi: Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States

DOI: https://doi.org/10.1016/j.ehpc.2020.200408
Journal volume & issue: Vol. 21
p. 200408

Abstract

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Chronic lymphocytic leukemia (CLL) is a neoplasm composed of monoclonal mature B lymphocytes. It demonstrates a heterogenous genomic landscape, commonly associated with karyotypic abnormalities. Here we report a case of CLL that demonstrated a rearrangement of the NOTCH2 gene with SEC22B, forming a novel fusion not previously reported in CLL.

Published in Human Pathology: Case Reports

ISSN: 2214-3300 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Pathology
Website: http://www.journals.elsevier.com/human-pathology-case-reports/

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