Frontiers in Pediatrics (Oct 2024)

Effect of teduglutide, a glucagon-like peptide-2 analog, in eosinophilic enterocolitis: a case report

  • Shoko Ogawa,
  • Ken-ichiro Konishi,
  • Kiyoshi Tanaka,
  • Hajime Takayasu,
  • Yoshimasa Uematsu,
  • Takashi Ito,
  • Hiroyuki Takahashi,
  • Yusuke Kumamoto

DOI
https://doi.org/10.3389/fped.2024.1457824
Journal volume & issue
Vol. 12

Abstract

Read online

We successfully treated a 4-year-old girl with short bowel syndrome and eosinophilic enterocolitis with teduglutide, a glucagon-like peptide-2 analog. Her eosinophilic enterocolitis was cured without relapse, and we were able to increase enteral nutrition. We found that teduglutide had an anti-inflammatory effect in this patient with eosinophilic gastrointestinal disease associated with short bowel syndrome. This report is the first to describe use of teduglutide in the treatment of eosinophilic gastrointestinal disease.

Keywords