Research Results in Pharmacology (Mar 2016)

PHARMACOLOGICAL CORRECTION OF L-NAME-INDUCED OXIDE DEFICIENCY WITH DERIVATIVES OF 3-(2,2,2- TRIMETHYLHYDRAZINIUM) PROPIONATE

  • Sophiya Ya. Skachilova,
  • Oleg Kesarev,
  • Lyudmila Danilenko,
  • Natalya Bystrova,
  • Alexandr Dolzhikov,
  • Sergej Nikolaev

DOI
https://doi.org/10.18413/2313-8971-2016-2-1-36-41
Journal volume & issue
Vol. 2, no. 1
pp. 36 – 41

Abstract

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This paper deals with the study of correction of L-NAME-induced endothelial dysfunction by means of 3-(2,2,2-trimethylhydrazinium) propionate derivatives. We have shown that 3-(2,2,2-trimethylhydrazinium) propionate and its derivatives reduced the expression of NOdeficient endothelial dysfunction induced by intraperitoneal administration of N-nitro L-arginine methyl ester (L-NAME), improved the parameters of endothelium-dependent vasodilation in response to administration of acetylcholine, and reduced the coefficient of endothelial dysfunction. It was revealed that the 5-hydroxinicotinate 3-(2,2,2-trimethylhydrazinium) potassium propionate has the most pronounced endothelioprotective effect.

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