Human Papilloma Virus16 and 18 Infection and the Cervical Cytology Changes in Combined Hormonal Contraceptive Users

Abstract

Objective: To evaluate the correlation between HPV-16 and 18 infection and the cervical cytology changes among combination hormonal contraceptives users. Methods: A cross-sectional study involved 40 women using combined hormonal contraceptive (oral or injection/DMPA contraceptive) and 40 women of non-hormonal contraceptive users was conducted in Dr. Wahidin Sudirohusodo hospital, some affiliated hospitals of Department of Obstetrics and Gynecology Faculty of Medicine, Universitas Hasanuddin and a private clinic in Makassar from November 2015 and April 2016. HPV 16 and 18 genotyping in cervix using PCR method and cervical cytology changes using liquid-based cytology (LBC) method were performed. HPV infection and cervical cytology changes were analysis based on Fisher’s test and chi-square test. Results: A significant difference found only in parity (p<0.05) between users and control of baseline characteristics. Neither users nor control were significantly associated with HPV-16 and 18 infection and changes in cervical cytology. Conclusion: Combined hormonal contraceptives are not correlated with HPV-16 and 18 infection and changes in cervical cytology. Keywords: cervix, combined hormonal contraceptive, human papilloma virus