Nature Communications (May 2018)
A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression
- Diego Farinello,
- Monika Wozińska,
- Elisa Lenti,
- Luca Genovese,
- Silvia Bianchessi,
- Edoardo Migliori,
- Nicolò Sacchetti,
- Alessia di Lillo,
- Maria Teresa Sabrina Bertilaccio,
- Claudia de Lalla,
- Roberta Valsecchi,
- Sabrina Bascones Gleave,
- David Lligé,
- Cristina Scielzo,
- Laura Mauri,
- Maria Grazia Ciampa,
- Lydia Scarfò,
- Rosa Bernardi,
- Dejan Lazarevic,
- Blanca Gonzalez-Farre,
- Lucia Bongiovanni,
- Elias Campo,
- Andrea Cerutti,
- Maurilio Ponzoni,
- Linda Pattini,
- Federico Caligaris-Cappio,
- Paolo Ghia,
- Andrea Brendolan
Affiliations
- Diego Farinello
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- Monika Wozińska
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- Elisa Lenti
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- Luca Genovese
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- Silvia Bianchessi
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- Edoardo Migliori
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- Nicolò Sacchetti
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- Alessia di Lillo
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- Maria Teresa Sabrina Bertilaccio
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- Claudia de Lalla
- Division of Immunology and Infection Disease, IRCCS, San Raffaele Scientific Institute
- Roberta Valsecchi
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- Sabrina Bascones Gleave
- Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- David Lligé
- Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- Cristina Scielzo
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- Laura Mauri
- Department of Medical Biotechnology and Translational Medicine, University of Milan
- Maria Grazia Ciampa
- Department of Medical Biotechnology and Translational Medicine, University of Milan
- Lydia Scarfò
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- Rosa Bernardi
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- Dejan Lazarevic
- Center of Translational Genomics and Bioinformatics, IRCCS, San Raffaele Scientific Institute
- Blanca Gonzalez-Farre
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic and University of Barcelona
- Lucia Bongiovanni
- Pathology Unit, IRCCS San Raffaele Scientific Institute
- Elias Campo
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic and University of Barcelona
- Andrea Cerutti
- Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)
- Maurilio Ponzoni
- Pathology Unit, IRCCS San Raffaele Scientific Institute
- Linda Pattini
- Department of Electronics, Information and Bioengineering, Politecnico di Milano
- Federico Caligaris-Cappio
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- Paolo Ghia
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- Andrea Brendolan
- Division of Experimental Oncology, IRCCS, San Raffaele Scientific Institute
- DOI
- https://doi.org/10.1038/s41467-018-04150-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
The stromal microenvironment plays a key role in the expansion of chronic lymphocytic leukemia. Here, the authors use the Eµ-TCL1 mouse model to show that leukemic B-cells induce the activation of retinoic acid synthesis in stromal cells of the lymphoid microenvironment, and that impacting on retinoic acid signalling via diet or chemical inhibition prolonged survival by preventing leukemia dissemination and accumulation in lymphoid tissues.
