Cohort profile: BioMD-Y (biopsychosocial factors of major depression in youth) – a biobank study on the molecular genetics and environmental factors of depression in children and adolescents in Munich
Elisabeth Binder,
Ellen Greimel,
Lisa Feldmann,
Charlotte Piechaczek,
Gerd Schulte-Körne,
Markus M Nöthen,
Inga Wermuth,
Darina Czamara,
Monika Rex-Haffner,
Aline Doreen Scherff,
Verena Pehl,
Petra Wagenbüchler,
Neda Ghotbi,
Antje-Kathrin Allgaier,
Franz Joseph Freisleder,
Eva C Beins,
Andreas J Forstner,
Marcus Ising
Affiliations
Elisabeth Binder
Department Genes and Environment, Max-Planck-Institute of Psychiatry, Munich, Germany
Ellen Greimel
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany
Lisa Feldmann
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany
Charlotte Piechaczek
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany
Gerd Schulte-Körne
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany
Markus M Nöthen
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
Inga Wermuth
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany
Darina Czamara
Department Genes and Environment, Max-Planck-Institute of Psychiatry, Munich, Germany
Monika Rex-Haffner
Department Genes and Environment, Max-Planck-Institute of Psychiatry, Munich, Germany
Aline Doreen Scherff
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany
Verena Pehl
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany
Petra Wagenbüchler
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany
Neda Ghotbi
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany
Antje-Kathrin Allgaier
Department of Human Sciences, Institute of Psychology, University of the Bundeswehr Munich, Munich, Germany
Franz Joseph Freisleder
kbo-Heckscher-Klinikum gGmbH, Munich, Germany
Eva C Beins
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
Andreas J Forstner
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
Marcus Ising
Max-Planck Institute of Psychiatry, Munich, Germany
Purpose BioMD-Y is a comprehensive biobank study of children and adolescents with major depression (MD) and their healthy peers in Germany, collecting a host of both biological and psychosocial information from the participants and their parents with the aim of exploring genetic and environmental risk and protective factors for MD in children and adolescents.Participants Children and adolescents aged 8–18 years are recruited to either the clinical case group (MD, diagnosis of MD disorder) or the typically developing control group (absence of any psychiatric condition).Findings to date To date, four publications on both genetic and environmental risk and resilience factors (including FKBP5, glucocorticoid receptor activation, polygenic risk scores, psychosocial and sociodemographic risk and resilience factors) have been published based on the BioMD-Y sample.Future plans Data collection is currently scheduled to continue into 2026. Research questions will be further addressed using available measures.
