Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2

Rui Li; Jingchen Shao; Young-June Jin; Haruya Kawase; Yu Ting Ong; Kerstin Troidl; Qi Quan; Lei Wang; Remy Bonnavion; Astrid Wietelmann; Francoise Helmbacher; Michael Potente; Johannes Graumann; Nina Wettschureck; Stefan Offermanns

doi:10.1038/s41467-023-37671-x

Nature Communications (Apr 2023)

Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2

Rui Li,
Jingchen Shao,
Young-June Jin,
Haruya Kawase,
Yu Ting Ong,
Kerstin Troidl,
Qi Quan,
Lei Wang,
Remy Bonnavion,
Astrid Wietelmann,
Francoise Helmbacher,
Michael Potente,
Johannes Graumann,
Nina Wettschureck,
Stefan Offermanns

Affiliations

Rui Li: Max Planck Institute for Heart and Lung Research, Department of Pharmacology
Jingchen Shao: Max Planck Institute for Heart and Lung Research, Department of Pharmacology
Young-June Jin: Max Planck Institute for Heart and Lung Research, Department of Pharmacology
Haruya Kawase: Max Planck Institute for Heart and Lung Research, Department of Pharmacology
Yu Ting Ong: Max Planck Institute for Heart and Lung Research, Angiogenesis & Metabolism Laboratory
Kerstin Troidl: Max Planck Institute for Heart and Lung Research, Department of Pharmacology
Qi Quan: Max Planck Institute for Heart and Lung Research, Department of Pharmacology
Lei Wang: Max Planck Institute for Heart and Lung Research, Department of Pharmacology
Remy Bonnavion: Max Planck Institute for Heart and Lung Research, Department of Pharmacology
Astrid Wietelmann: Max Planck Institute for Heart and Lung Research, Small Animal Imaging Service Group
Francoise Helmbacher: Aix Marseille Université, CNRS, IBDM UMR 7288, Parc Scientifique de Luminy, Case 907
Michael Potente: Max Planck Institute for Heart and Lung Research, Angiogenesis & Metabolism Laboratory
Johannes Graumann: Max Planck Institute for Heart and Lung Research, Biomolecular Mass Spectrometry Service Group
Nina Wettschureck: Max Planck Institute for Heart and Lung Research, Department of Pharmacology
Stefan Offermanns: Max Planck Institute for Heart and Lung Research, Department of Pharmacology

DOI: https://doi.org/10.1038/s41467-023-37671-x
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 17

Abstract

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The authors report that endothelial protocadherin FAT1 inhibits endothelial proliferation and angiogenesis by promoting degradation of the transcriptional cofactors YAP and TAZ by direct interaction with the E3 ubiquitin ligase Mind Bomb-2 (MIB2).

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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