Морфологія (Jan 2007)
Immunohistochemical profile of laryngeal cancers with different clinical course and efficiency of treatment.
Abstract
The cancer of larynx is one of the most significant medical problems because of its high prevalence, high mortality and low survival rate. The retrospective analysis of specimens of 187 patients suffering from laryngeal squamous cell carcinoma of stage III-IV was performed. The purpose of our study was to substantiate the appropriateness of assessment of immunomorphological profile in estimation of biological behaviour of laryngeal cancer for prediction its clinical course and choice of optimal treatment. The routine histological examination with determination of type, histopathological grading and extention of tumors was performed. Molecular markers, such as CK19, CK34βЕ12, Ki-67, p53 and bcl-2 were analyzed by immunohistochemistry. Our findings were compared with the clinical course, presence of regional and distant metastasis, rate of relapses, one-year survival rate, and efficiency of treatment. The significant distinctions in marker expression among tumors with different clinical course and efficiency of treatment were determined which prove these markers prognostic significance. The cancers of the larynx with unfavorable clinical course had high proliferative activity, expression of р53, СК19 and low expression of СК34. The tumors that responded well to the treatment had high expression of р53 and low expression of bcl-2. The radiosensitive tumors also had high proliferative activity. The cancers which did not respond well to treatment had high expression of bcl-2 that allowed us to consider this marker to be independent factor of tumor resistance to treatment. These data give us the possibility to individualize treatment approaches to patients with laryngeal cancer.
