Degree and Rate of Growth Discordance in Dichorionic Twins Conceived by In Vitro Fertilization

Amira S. Egic; Donka V. Mojovic; Zagorka M. Milovanovic; Aleksandar B. Jurisic; Ljubomir P. Srbinovic; Suzana P. Krsmanovic; Natasa T. Karadzov-Orlic

doi:10.1155/2014/543728

Obstetrics and Gynecology International (Jan 2014)

Degree and Rate of Growth Discordance in Dichorionic Twins Conceived by In Vitro Fertilization

Amira S. Egic,
Donka V. Mojovic,
Zagorka M. Milovanovic,
Aleksandar B. Jurisic,
Ljubomir P. Srbinovic,
Suzana P. Krsmanovic,
Natasa T. Karadzov-Orlic

Affiliations

Amira S. Egic: High-Risk Pregnancy Department, Obstetric and Gynecology Clinic “Narodni Front”, University of Belgrade, Street Kraljice Natalije 62, 11000 Belgrade, Serbia
Donka V. Mojovic: High-Risk Pregnancy Department, Obstetric and Gynecology Clinic “Narodni Front”, University of Belgrade, Street Kraljice Natalije 62, 11000 Belgrade, Serbia
Zagorka M. Milovanovic: High-Risk Pregnancy Department, Obstetric and Gynecology Clinic “Narodni Front”, University of Belgrade, Street Kraljice Natalije 62, 11000 Belgrade, Serbia
Aleksandar B. Jurisic: High-Risk Pregnancy Department, Obstetric and Gynecology Clinic “Narodni Front”, University of Belgrade, Street Kraljice Natalije 62, 11000 Belgrade, Serbia
Ljubomir P. Srbinovic: High-Risk Pregnancy Department, Obstetric and Gynecology Clinic “Narodni Front”, University of Belgrade, Street Kraljice Natalije 62, 11000 Belgrade, Serbia
Suzana P. Krsmanovic: High-Risk Pregnancy Department, Obstetric and Gynecology Clinic “Narodni Front”, University of Belgrade, Street Kraljice Natalije 62, 11000 Belgrade, Serbia
Natasa T. Karadzov-Orlic: High-Risk Pregnancy Department, Obstetric and Gynecology Clinic “Narodni Front”, University of Belgrade, Street Kraljice Natalije 62, 11000 Belgrade, Serbia

DOI: https://doi.org/10.1155/2014/543728
Journal volume & issue: Vol. 2014

Abstract

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Objective. Our objective was to estimate degree and rate of discordant growth and its impact on perinatal outcome in dichorionic twin pregnancies conceived by in vitro fertilization (IVF) compared to those conceived spontaneously. Study Design. Growth discordance was defined as 90th percentiles for the study population. Adverse perinatal outcome was defined as 5-minute Apgar score <7 and/or admission to neonatal intensive care unit. Results. In the total study population of dichorionic twins (176 conceived by IVF and 215 spontaneously), 30% discordant growth represented the 90th percentile. After adjusting for gestational age, discordant twins conceived by IVF or spontaneously were at higher risk for adverse perinatal outcome (hazard ratio 4.4; 95% CI 2.4–8.3, P<0.0001; hazard ratio 2.5; 95% CI 1.5–4.4, P=0.001, resp.). Similar rates of 5-minute Apgar score <7, admission to neonatal intensive care unit, and delivery <34 weeks were found between discordant twins conceived by IVF and those conceived spontaneously. Conclusion. Dichorionic twins conceived by IVF are at similar risk for the rate and degree of discordant growth and adverse perinatal outcome compared to dichorionic twins conceived spontaneously.

Published in Obstetrics and Gynecology International

ISSN: 1687-9589 (Print); 1687-9597 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Gynecology and obstetrics
Website: https://www.hindawi.com/journals/ogi/

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