COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study
Cristiane de Freitas Paganoti,
Rafaela Alkmin da Costa,
Aris T. Papageorghiou,
Fabrício da Silva Costa,
Silvana Maria Quintana,
Luciana Graziela de Godoi,
Nátaly Adriana Jiménez Monroy,
Agatha Sacramento Rodrigues,
Rossana Pulcineli Vieira Francisco
Affiliations
Cristiane de Freitas Paganoti
Divisão de Clinica Obstetrica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, 255 Dr Eneas Carvalho de Aguiar Avenue, 10th floor, São Paulo 05403-000, Brazil
Rafaela Alkmin da Costa
Divisão de Clinica Obstetrica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, 255 Dr Eneas Carvalho de Aguiar Avenue, 10th floor, São Paulo 05403-000, Brazil
Aris T. Papageorghiou
Nuffield Department of Women’s and Reproductive Health, University of Oxford, Women’s Centre, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
Fabrício da Silva Costa
Maternal Fetal Medicine Unit, Gold Coast University Hospital, School of Medicine, Griffith University, Gold Coast 4222, Australia
Silvana Maria Quintana
Gynecology and Obstetric Department, Ribeirão Preto Medical School, University of São Paulo, 3900 Bandeirantes Avenue, Ribeirão Preto, São Paulo 14049-900, Brazil
Luciana Graziela de Godoi
Departamento de Estatística, Universidade Federal do Espírito Santo, 514 Fernando Ferrari Avenue, Goiabeira, Vitória 29075-910, Brazil
Nátaly Adriana Jiménez Monroy
Departamento de Estatística, Universidade Federal do Espírito Santo, 514 Fernando Ferrari Avenue, Goiabeira, Vitória 29075-910, Brazil
Agatha Sacramento Rodrigues
Departamento de Estatística, Universidade Federal do Espírito Santo, 514 Fernando Ferrari Avenue, Goiabeira, Vitória 29075-910, Brazil
Rossana Pulcineli Vieira Francisco
Disciplina de Obstetrícia, Departamento de Obstetrícia e Ginecologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-070, Brazil
The coronavirus disease 2019 (COVID-19) pandemic has had deleterious effects among the obstetric population. Pregnant and postpartum women constitute a high-risk group for severe COVID-19. Vaccination reduces the risk of infection, but it is not known whether women who become infected despite vaccination have a milder course of disease than those who had not been vaccinated. This retrospective cohort study evaluated whether vaccination reduces the severity of COVID-19 infection, as measured by severe maternal morbidity and mortality among hospitalized pregnant and postpartum individuals. A total of 2284 pregnant and postpartum women hospitalized with severe COVID-19 were included. Those who did and who did not receive COVID-19 vaccination were compared. The rates of intensive care unit admission, intubation, and mortality were significantly lower among subjects in the vaccinated group (p p p < 0.001, respectively). The numbers of patients who needed to be vaccinated to avoid one case of intensive care unit admission, intubation, or death due to COVID-19 were 7, 7, and 9, respectively. The COVID-19 vaccine offers protective effects against intensive care unit admission, intubation, and death in hospitalized pregnant and postpartum women with severe SARS-CoV-2-induced SARS.
