Immune Evasion of G-CSF and GM-CSF in Lung Cancer

Abstract

Tumor immune evasion is a complex process that involves various mechanisms, such as antigen recognition restriction, immune system suppression, and T cell exhaustion. The tumor microenvironment contains various immune cells involved in immune evasion. Recent studies have demonstrated that granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) induce immune evasion in lung cancer by modulating neutrophils and myeloid-derived suppressor cells. Here we describe the origin and function of G-CSF and GM-CSF, particularly their role in immune evasion in lung cancer. In addition, their effects on programmed death-ligand 1 expression and clinical implications are discussed.

Keywords

• granulocyte colony-stimulating factor
• granulocyte-macrophage colony-stimulating factor
• neutrophils
• myeloid-derived suppressor cell
• programmed death-ligand 1
• immune evasion