Prescription trend and lactic acidosis in patients prescribed metformin before and after the revision of package insert for allowing metformin administration to patients with moderately decreased kidney function based on real-world data from MID-NET® in Japan

• Takashi Waki,
• Yusuke Okada,
• Yuki Kinoshita,
• Kazuhiro Kajiyama,
• Chieko Ishiguro,
• Yuki Nakazato,
• Ryota Kimura,
• Harumi Maniwa,
• Naoya Horiuchi,
• Toyotaka Iguchi,
• Yoshiaki Uyama

Affiliations

Takashi Waki

Office of Medical Informatics and Epidemiology, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan

Yusuke Okada

Office of Medical Informatics and Epidemiology, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan

Yuki Kinoshita

Office of Medical Informatics and Epidemiology, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan

Kazuhiro Kajiyama

Office of Medical Informatics and Epidemiology, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan

Chieko Ishiguro

Office of Medical Informatics and Epidemiology, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan

Yuki Nakazato

Office of Pharmacovigilance I, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan

Ryota Kimura

Office of Pharmacovigilance I, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan

Harumi Maniwa

Office of Pharmacovigilance I, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan

Naoya Horiuchi

Office of Pharmacovigilance I, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan

Toyotaka Iguchi

Office of Pharmacovigilance II, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan

Yoshiaki Uyama

Office of Medical Informatics and Epidemiology, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan