Microgel Encapsulated Mesoporous Silica Nanoparticles for Releasing Wnt16 to Synergistically Treat Temporomandibular Joint Osteoarthritis

Yan Zhu; Lingyan Cao; Mu Yuan; Xuzhuo Chen; Xinru Xie; Minhan Li; Chi Yang; Xiansong Wang; Zhigui Ma

doi:10.1002/advs.202404396

Advanced Science (Nov 2024)

Microgel Encapsulated Mesoporous Silica Nanoparticles for Releasing Wnt16 to Synergistically Treat Temporomandibular Joint Osteoarthritis

Yan Zhu,
Lingyan Cao,
Mu Yuan,
Xuzhuo Chen,
Xinru Xie,
Minhan Li,
Chi Yang,
Xiansong Wang,
Zhigui Ma

Affiliations

Yan Zhu: Department of Oral Surgery Shanghai Ninth People's Hospital College of Stomatology Shanghai Jiao tong University School of medicine National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences Shanghai 200011 China
Lingyan Cao: National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Engineering Research Center of Advanced Dental Technology and Materials Shanghai 200011 China
Mu Yuan: Department of Oral Surgery Shanghai Ninth People's Hospital College of Stomatology Shanghai Jiao tong University School of medicine National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences Shanghai 200011 China
Xuzhuo Chen: Department of Oral Surgery Shanghai Ninth People's Hospital College of Stomatology Shanghai Jiao tong University School of medicine National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences Shanghai 200011 China
Xinru Xie: Department of Oral Surgery Shanghai Ninth People's Hospital College of Stomatology Shanghai Jiao tong University School of medicine National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences Shanghai 200011 China
Minhan Li: Department of Oral Surgery Shanghai Ninth People's Hospital College of Stomatology Shanghai Jiao tong University School of medicine National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences Shanghai 200011 China
Chi Yang: Department of Oral Surgery Shanghai Ninth People's Hospital College of Stomatology Shanghai Jiao tong University School of medicine National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences Shanghai 200011 China
Xiansong Wang: Department of Plastic and Reconstructive Surgery Shanghai Key Laboratory of Tissue Engineering Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200011 China
Zhigui Ma: Department of Oral Surgery Shanghai Ninth People's Hospital College of Stomatology Shanghai Jiao tong University School of medicine National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences Shanghai 200011 China

DOI: https://doi.org/10.1002/advs.202404396
Journal volume & issue: Vol. 11, no. 41
pp. n/a – n/a

Abstract

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Abstract Temporomandibular joint osteoarthritis (TMJOA) is a commonly encountered degenerative joint disease in oral and maxillofacial surgery. Recent studies have shown that the excessive unbalanced activation of Wnt/β‐catenin signaling is connected with the pathogenesis of TMJOA and due to the inability to inhibit the over‐activated Wnt pathway, while Wnt16‐deficient mice has a more severe Knee OA. However, the efficacy of direct intra‐TMJ injection of Wnt16 for the relief of TMJOA is still not directly confirmed. Moreover, small‐molecule drugs such as Wnt16 usually exhibit short‐lived efficacy and poor treatment adherence. Therefore, in order to obtain a stable release of Wnt16 both in the short and long term, this study fabricates a double‐layer slow‐release Wnt16 carrier based on mesoporous silica nanospheres (MSNs) encased within hyaluronic acid (HA) hydrogels. The biofunctional hydrogel HA/Wnt16@MSN is analyzed both in vitro and in vivo to evaluate the treatment of TMJOA. As a result, it shows superior pro‐cartilage matrix restoration and inhibition of osteoclastogenesis ability, and effectively inhibits the over‐activation of the Wnt/β‐catenin pathway. Taken together, biofunctional hydrogel HA/Wnt16@MSN is a promising candidate for the treatment of TMJOA.

Published in Advanced Science

ISSN: 2198-3844 (Online)
Publisher: Wiley
Country of publisher: Germany
LCC subjects: Science
Website: https://onlinelibrary.wiley.com/journal/21983844

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