Nature Communications (Dec 2020)

Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction

  • Florian Fäßler,
  • Georgi Dimchev,
  • Victor-Valentin Hodirnau,
  • William Wan,
  • Florian K. M. Schur

DOI
https://doi.org/10.1038/s41467-020-20286-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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The actin-related protein (Arp)2/3 complex nucleates branched actin filament networks pivotal for cell migration, endocytosis and pathogen infection. Here, authors report a 9.0 Å resolution structure of the actin filament Arp2/3 complex branch junction in cells using cryo-electron tomography and subtomogram averaging.