Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction

Florian Fäßler; Georgi Dimchev; Victor-Valentin Hodirnau; William Wan; Florian K. M. Schur

doi:10.1038/s41467-020-20286-x

Nature Communications (Dec 2020)

Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction

Florian Fäßler,
Georgi Dimchev,
Victor-Valentin Hodirnau,
William Wan,
Florian K. M. Schur

Affiliations

Florian Fäßler: Institute of Science and Technology (IST) Austria
Georgi Dimchev: Institute of Science and Technology (IST) Austria
Victor-Valentin Hodirnau: Institute of Science and Technology (IST) Austria
William Wan: Department of Biochemistry and Center for Structural Biology, Vanderbilt University
Florian K. M. Schur: Institute of Science and Technology (IST) Austria

DOI: https://doi.org/10.1038/s41467-020-20286-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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The actin-related protein (Arp)2/3 complex nucleates branched actin filament networks pivotal for cell migration, endocytosis and pathogen infection. Here, authors report a 9.0 Å resolution structure of the actin filament Arp2/3 complex branch junction in cells using cryo-electron tomography and subtomogram averaging.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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