Communications Biology (Apr 2021)

hReg-CNCC reconstructs a regulatory network in human cranial neural crest cells and annotates variants in a developmental context

  • Zhanying Feng,
  • Zhana Duren,
  • Ziyi Xiong,
  • Sijia Wang,
  • Fan Liu,
  • Wing Hung Wong,
  • Yong Wang

DOI
https://doi.org/10.1038/s42003-021-01970-0
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 16

Abstract

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Zhanying Feng et al. present hReg-CNCC, a high-quality gene regulatory network for human cranial neural crest cells (CNCCs) constructed by consensus optimization modeling. It may be useful in interpreting genetic variants involved in embryonic development by linking the cis-regulatory sequences in this network with GWAS SNPs, disease risk loci, and evolutionarily-conserved regions of the genome.