Exploring Serum Copeptin and Hematological Profile: A Comparative Analysis after Intradermal versus Intramuscular Porcine Reproductive and Respiratory Syndrome Virus Vaccination in Piglets
Georgios Maragkakis,
Eleni G. Katsogiannou,
Georgios I. Papakonstantinou,
Laskarina-Maria Korou,
Serafeim C. Chaintoutis,
Panagiotis Konstantopoulos,
Despoina N. Perrea,
Georgios Christodoulopoulos,
Labrini V. Athanasiou,
Vasileios G. Papatsiros
Affiliations
Georgios Maragkakis
Clinic of Medicine, Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, 43100 Karditsa, Greece
Eleni G. Katsogiannou
Clinic of Medicine, Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, 43100 Karditsa, Greece
Georgios I. Papakonstantinou
Clinic of Medicine, Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, 43100 Karditsa, Greece
Laskarina-Maria Korou
Laboratory for Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Serafeim C. Chaintoutis
Diagnostic Laboratory, School of Veterinary Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Panagiotis Konstantopoulos
Laboratory for Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Despoina N. Perrea
Laboratory for Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
Georgios Christodoulopoulos
Department of Animal Science, Agricultural University of Athens, 75 Iera Odos Street, Votanikos, 11855 Athens, Greece
Labrini V. Athanasiou
Clinic of Medicine, Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, 43100 Karditsa, Greece
Vasileios G. Papatsiros
Clinic of Medicine, Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, 43100 Karditsa, Greece
This study aimed to investigate the impact of intradermal (ID) and intramuscular (IM) vaccination with a porcine reproductive and respiratory syndrome virus (PRRSV)-modified live vaccine (MLV) in piglets on serum copeptin levels and hematological profile. This study included 104 suckling piglets (2 weeks of age) from a commercial farrow-to-finish pig farm suffering from positive unstable PRRSV status. Animals were assigned to four groups, with two replicates (13 piglets/group/replicate); group A: IM vaccination with a PRRSV MLV vaccine, group B: ID vaccination with the same vaccine, group C: ID of Diluvac Forte, and group D: IM of Diluvac Forte. Blood samples were collected from the same three pigs/group/replicate at 4, 7, and 10 weeks of age. Blood samples were used for the performance of the complete blood count, and they were also examined by PCR for PRRSV and by ELISA for copeptin. No significant differences in serum copeptin levels and the number of blood cell counts (packed cell volume—PCV, numbers of white blood cells—WBCs, and platelets number—PLTs) were noticed in the same group over time and among groups. In conclusion, it seems that the vaccination against PRRSV does not affect the levels of the released copeptin. Based on our results, the measurement of serum copeptin could not be proposed as a potential stress biomarker in pigs.
