Molecular Analysis of Short- versus Long-Term Survivors of High-Grade Serous Ovarian Carcinoma

Elaine Stur; Emine Bayraktar; Graziela Zibetti Dal Molin; Sherry Y. Wu; Lingegowda S. Mangala; Hui Yao; Ying Wang; Prahlad T. Ram; Sara Corvigno; Hu Chen; Han Liang; Shelley S. Tworoger; Douglas A. Levine; Susan K. Lutgendorf; Jinsong Liu; Kathleen N. Moore; Keith A. Baggerly; Beth Y. Karlan; Anil K. Sood

doi:10.3390/cancers14174198

Cancers (Aug 2022)

Molecular Analysis of Short- versus Long-Term Survivors of High-Grade Serous Ovarian Carcinoma

Elaine Stur,
Emine Bayraktar,
Graziela Zibetti Dal Molin,
Sherry Y. Wu,
Lingegowda S. Mangala,
Hui Yao,
Ying Wang,
Prahlad T. Ram,
Sara Corvigno,
Hu Chen,
Han Liang,
Shelley S. Tworoger,
Douglas A. Levine,
Susan K. Lutgendorf,
Jinsong Liu,
Kathleen N. Moore,
Keith A. Baggerly,
Beth Y. Karlan,
Anil K. Sood

Affiliations

Elaine Stur: Department of Gynecologic Oncology & Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Emine Bayraktar: Department of Gynecologic Oncology & Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Graziela Zibetti Dal Molin: Medical Oncology Department, Beneficencia Portuguesa de Sao Paulo, Sao Paulo 13900-400, Brazil
Sherry Y. Wu: School of Biomedical Sciences, The University of Queensland, St. Lucia, QLD 4072, Australia
Lingegowda S. Mangala: Department of Gynecologic Oncology & Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Hui Yao: Department of Bioinformatics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Ying Wang: Department of Bioinformatics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Prahlad T. Ram: Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Sara Corvigno: Department of Gynecologic Oncology & Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Hu Chen: Department of Bioinformatics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Han Liang: Department of Bioinformatics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Shelley S. Tworoger: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL 33612, USA
Douglas A. Levine: Division of Gynecologic Oncology, New York University, New York, NY 11580, USA
Susan K. Lutgendorf: Department of Psychological & Brain Sciences, The University of Iowa, Iowa City, IA 52242, USA
Jinsong Liu: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Kathleen N. Moore: Department of Gynecologic Oncology, The University of Oklahoma, Oklahoma City, OK 73117, USA
Keith A. Baggerly: Department of Bioinformatics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Beth Y. Karlan: Department of Obstetrics and Gynecology, University of California, Los Angeles, CA 90095, USA
Anil K. Sood: Department of Gynecologic Oncology & Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

DOI: https://doi.org/10.3390/cancers14174198
Journal volume & issue: Vol. 14, no. 17
p. 4198

Abstract

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Despite having similar histologic features, patients with high-grade serous ovarian carcinoma (HGSC) often experience highly variable outcomes. The underlying determinants for long-term survival (LTS, ≥10 years) versus short-term survival (STS, 2; false discovery rate TMEM62) was found to be related to LTS. CIBERSORT analysis showed that T cells (follicular helper) were found at higher levels in tumors from LTS than STS groups. In vitro data using OVCAR5 and OVCAR8 cells showed decreased proliferation with TMEM62 overexpression and positive correlation with a longevity-regulating pathway (KEGG HSA04213) at the RNA level. In vivo analysis using the OVCAR8-TMEM62-TetON model showed decreased tumor burden in mice with high- vs. low-expressing TMEM62 tumors. Our results demonstrate that restoring TMEM62 may be a novel approach for treatment of HGSC. These findings may have implications for biomarker and intervention strategies to help improve patient outcomes

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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