UPF1/SMG7-dependent microRNA-mediated gene regulation

Jungyun Park; Jwa-Won Seo; Narae Ahn; Seokju Park; Jungwook Hwang; Jin-Wu Nam

doi:10.1038/s41467-019-12123-7

Nature Communications (Sep 2019)

UPF1/SMG7-dependent microRNA-mediated gene regulation

Jungyun Park,
Jwa-Won Seo,
Narae Ahn,
Seokju Park,
Jungwook Hwang,
Jin-Wu Nam

Affiliations

Jungyun Park: Graduate School for Biomedical Science & Engineering, Hanyang University
Jwa-Won Seo: Department of Life Science, College of Natural Sciences, Hanyang University
Narae Ahn: Graduate School for Biomedical Science & Engineering, Hanyang University
Seokju Park: Department of Life Science, College of Natural Sciences, Hanyang University
Jungwook Hwang: Graduate School for Biomedical Science & Engineering, Hanyang University
Jin-Wu Nam: Department of Life Science, College of Natural Sciences, Hanyang University

DOI: https://doi.org/10.1038/s41467-019-12123-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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UPF1 mediates the decay of target mRNA in a 3′ untranslated region (UTR)-length-dependent manner. Here the authors reveal that the 3′UTR-length-dependent regulation of UPF1-dependent mRNA decay occurs through EJC-independent but miRNA-dependent regulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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