OncoTargets and Therapy (Jul 2020)
Long Non-Coding RNAs in Drug Resistance of Breast Cancer
Abstract
Tonghua Du, Ying Shi, Shengnan Xu, Xiaoyu Wan, Haiyin Sun, Bin Liu Department of Breast Surgery, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of ChinaCorrespondence: Bin LiuDepartment of Breast Surgery, The Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun, Jilin 130041, People’s Republic of ChinaTel +86 13844823515Email [email protected]: Breast cancer (BC) is the most common cancer and the leading cause of death in women. Advances in early diagnosis and therapeutic strategies have decreased the mortality of BC and improved the prognosis of patients to some extent. However, the development of drug resistance has limited the success rate of systemic therapies. Long non-coding RNAs (lncRNAs) are involved in drug resistance in BC via various mechanisms, which contribute to a complex regulatory network. In this review, we summarize the latest findings on the mechanisms underlying drug resistance modulated by lncRNAs in BC. In addition, we discuss the potential clinical applications of lncRNAs as targeted molecular therapy against drug resistance in BC.Keywords: long non-coding RNA, lncRNA, drug resistance, breast cancer, mechanism
