RNA N6-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications

Qin Dang; Bo Shao; Bo Shao; Quanbo Zhou; Chen Chen; Chen Chen; Yaxin Guo; Yaxin Guo; Yaxin Guo; Guixian Wang; Jinbo Liu; Quancheng Kan; Weitang Yuan; Zhenqiang Sun

doi:10.3389/fonc.2021.681781

Frontiers in Oncology (Jun 2021)

RNA N6-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications

Qin Dang,
Bo Shao,
Bo Shao,
Quanbo Zhou,
Chen Chen,
Chen Chen,
Yaxin Guo,
Yaxin Guo,
Yaxin Guo,
Guixian Wang,
Jinbo Liu,
Quancheng Kan,
Weitang Yuan,
Zhenqiang Sun

Affiliations

Qin Dang: Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Bo Shao: Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Bo Shao: Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China
Quanbo Zhou: Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Chen Chen: Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China
Chen Chen: School of Life Sciences, Zhengzhou University, Zhengzhou, China
Yaxin Guo: Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China
Yaxin Guo: Department of Basic Medical, Academy of Medical Sciences of Zhengzhou University, Zhengzhou, China
Yaxin Guo: Henan Academy of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
Guixian Wang: Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Jinbo Liu: Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Quancheng Kan: Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Weitang Yuan: Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Zhenqiang Sun: Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

DOI: https://doi.org/10.3389/fonc.2021.681781
Journal volume & issue: Vol. 11

Abstract

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Cancer metastasis is a symptom of adverse prognosis, a prime origin of therapy failure, and a lethal challenge for cancer patients. N6-methyladenosine (m6A), the most prevailing modification in messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs) of higher eukaryotes, has attracted increasing attention. Growing studies have verified the pivotal roles of m6A methylation in controlling mRNAs and ncRNAs in diverse physiological processes. Remarkably, recent findings have showed that aberrant methylation of m6A-related RNAs could influence cancer metastasis. In this review, we illuminate how m6A modifiers act on mRNAs and ncRNAs and modulate metastasis in several cancers, and put forward the clinical application prospects of m6A methylation.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

About the journal

Abstract

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