Nature Communications (Jul 2019)

Highly atroposelective synthesis of nonbiaryl naphthalene-1,2-diamine N-C atropisomers through direct enantioselective C-H amination

  • He-Yuan Bai,
  • Fu-Xin Tan,
  • Tuan-Qing Liu,
  • Guo-Dong Zhu,
  • Jin-Miao Tian,
  • Tong-Mei Ding,
  • Zhi-Min Chen,
  • Shu-Yu Zhang

DOI
https://doi.org/10.1038/s41467-019-10858-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 9

Abstract

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Atropisomers with a chiral C-N axis are useful for natural products synthesis and as ligands in asymmetric catalysis. Here, the authors reportt a π-π interaction and dual H-bond concerted control strategy in enantioselective C-H amination affording configurationally stable N-C atropisomers.