Development of nanocapsule suspensions and nanocapsule spray-dried powders containing melatonin

Abstract

Nanocapsule suspensions containing melatonin were prepared by interfacial deposition method and characterized (size, morphological aspect and encapsulation efficiency). The formulation parameters studied were the oil nature, the type of surfactants and the type of polymer. The melatonin-encapsulation efficiency ranged between 30% and 56% and polymer nature was the parameter that more influenced the characteristics of suspensions. According to the highest encapsulation efficiency, the nanocapsules prepared with Eudragit S100® were selected to be spray-dried in order to improve the physical stability of suspension and to control the release of melatonin. The melatonin-loaded nanocapsule spray-dried powder presented encapsulation efficiency of the 93% and no morphological alterations were observed after 12 months of storage. This system showed a controlled release profile in comparison to the dissolution of the pure melatonin. The release profile was fitted to monoexponential model and the melatonin release mechanism was based on swelling and dissolution of the polymer.

Keywords

• melatonin
• nanocapsules
• nanoparticles
• spray-dried powders