Nature Communications (Nov 2018)

Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function

  • Fangjie Wang,
  • Meng Meng,
  • Banghui Mo,
  • Yao Yang,
  • Yan Ji,
  • Pei Huang,
  • Wenjing Lai,
  • Xiaodong Pan,
  • Tingting You,
  • Hongqin Luo,
  • Xiao Guan,
  • Yafei Deng,
  • Shunzong Yuan,
  • Jianhong Chu,
  • Michael Namaka,
  • Tiffany Hughes,
  • Lilin Ye,
  • Jianhua Yu,
  • Xiaohui Li,
  • Youcai Deng

DOI
https://doi.org/10.1038/s41467-018-07277-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 17

Abstract

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The metabolic regulator protein family, mTOR, regulate natural killer (NK) cell development and function, but the underlying mechanism is unclear. Here, the authors show that Raptor/mTORC1 and Rictor/mTORC2 form a feedback crosstalk network to variegate cytokine and cellular signaling and modulate NK maturation and effector functions.