Effects of Pranoprofen on the retinal structure and serum levels of VEGF in patients with cataract surgery

Abstract

AIM: To evaluate the effects of pranoprofen on the retinal structure and serum levels of vascular endothelial growth factor(VEGF)in patients with cataract surgery.METHODS: One hundred and seventy two cataract patients(200 eyes)were enrolled in this study. All the patients were randomly divided into observation group and control group. The patients of observation group were treated with pranoprofen combined with normal post-operative therapy for 1mo. We set 4 points(1d, 7d, 15d and 30d after surgery)to dynamically analyze the fluctuation of inflammation score, central macular retinal thickness(CMT), macular foveola retinal thickness(MFRT), and the light receptor inner segment and outer segment layer(IS/OS). We set two points(before and 30d after surgery)to dynamically observe the alteration of superoxide dismutase(SOD), malondialdehyde(MDA)and VEGF.RESULTS: The levels of inflammation index in control group were higher than those in observation group 7d, 15d and 30d after surgery, respectively(PPPPPPPCONCLUSION: Pranoprofen considerably relieve levels of inflammation injury and down-regulate circulating levels of VEGF, which contributes its promotion in the recovery of retinal structure after surgery.

Keywords

• pranoprofen
• cataract
• retinal structure
• vascular endothelial growth factor