The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases
Camino San Martin Ruano,
Francisco Miralles,
Céline Méhats,
Daniel Vaiman
Affiliations
Camino San Martin Ruano
Institut Cochin Departement Development Reproduction Cancer, U1016 INSERM, UMR8104 CNRS, Université de Paris, 24 Rue du Faubourg St Jacques, 75014 Paris, France
Francisco Miralles
Institut Cochin Departement Development Reproduction Cancer, U1016 INSERM, UMR8104 CNRS, Université de Paris, 24 Rue du Faubourg St Jacques, 75014 Paris, France
Céline Méhats
Institut Cochin Departement Development Reproduction Cancer, U1016 INSERM, UMR8104 CNRS, Université de Paris, 24 Rue du Faubourg St Jacques, 75014 Paris, France
Daniel Vaiman
Institut Cochin Departement Development Reproduction Cancer, U1016 INSERM, UMR8104 CNRS, Université de Paris, 24 Rue du Faubourg St Jacques, 75014 Paris, France
Oxidative stress (OS) plays a pivotal role in placental development; however, abnormal loads in oxidative stress molecules may overwhelm the placental defense mechanisms and cause pathological situations. The environment in which the mother evolves triggers an exposure of the placental tissue to chemical, physical, and biological agents of OS, with potential pathological consequences. Here we shortly review the physiological and developmental functions of OS in the placenta, and present a series of environmental pollutants inducing placental oxidative stress, for which some insights regarding the underlying mechanisms have been proposed, leading to a recapitulation of the noxious effects of OS of environmental origin upon the human placenta.
