Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging
Mengdi Yu,
Hongxia Zhang,
Brian Wang,
Yinuo Zhang,
Xiaoying Zheng,
Bei Shao,
Qichuan Zhuge,
Kunlin Jin
Affiliations
Mengdi Yu
Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Hongxia Zhang
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Brian Wang
Pathnova Laboratories Pte. Ltd. 1 Research Link, Singapore 117604, Singapore
Yinuo Zhang
Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Xiaoying Zheng
Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Bei Shao
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Qichuan Zhuge
Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Kunlin Jin
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Aging is a fundamental biological process accompanied by a general decline in tissue function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive impairment or dementia, will become a growing public health issue. Aging is also a great risk factor for many age-related diseases. Nowadays, people want not only to live longer but also healthier. Therefore, there is a critical need in understanding the underlying cellular and molecular mechanisms regulating aging that will allow us to modify the aging process for healthy aging and alleviate age-related disease. Here, we reviewed the recent breakthroughs in the mechanistic understanding of biological aging, focusing on the adenosine monophosphate-activated kinase (AMPK), Sirtuin 1 (SIRT1) and mammalian target of rapamycin (mTOR) pathways, which are currently considered critical for aging. We also discussed how these proteins and pathways may potentially interact with each other to regulate aging. We further described how the knowledge of these pathways may lead to new interventions for antiaging and against age-related disease.
