International Journal of General Medicine (Oct 2023)

The Ratio of Contrast Volume/Glomerular Filtration Rate and Urine NGAL Predicts the Progression of Acute Kidney Injury to Chronic Kidney Disease in Patients After Planned Percutaneous Coronary Intervention

  • Nguyen Duy T,
  • Dao Bui Quy Q,
  • Nguyen Duc L,
  • Ho Viet Le D,
  • Le Ha K,
  • Do Gia T,
  • Nguyen Trung K,
  • Nguyen Van T,
  • Nguyen Oanh O,
  • Le Viet T

Journal volume & issue
Vol. Volume 16
pp. 4525 – 4535

Abstract

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Toan Nguyen Duy,1,2 Quyen Dao Bui Quy,3 Loc Nguyen Duc,4 Diem Ho Viet Le,5 Khoa Le Ha,6 Tuyen Do Gia,6 Kien Nguyen Trung,1,2 Tam Nguyen Van,1,2 Oanh Nguyen Oanh,1,2 Thang Le Viet1,2 1Military Hospital 103, Hanoi, Vietnam; 2Vietnam Military Medical University, Hanoi, Vietnam; 3Cho Ray Hospital, Ho Chi Minh, Vietnam; 4An Sinh Hospital, Ho Chi Minh, Vietnam; 5Link-02 Clinic, Pham Ngoc Thach, Da Lat, Lam Dong, Vietnam; 6Hanoi Medical University, Hanoi, VietnamCorrespondence: Thang Le Viet, Military Hospital 103, Vietnam Military Medical University, Department of Nephrology and Hemodialysis, 261 Phung Hung, Ha Dong, Hanoi, Vietnam, Tel +84982249968, Email [email protected]: To evaluate the value of contrast volume/glomerular filtration ratio (Vc/eGFR ratio) and urine Neutrophil Gelatinase-Associated Lipocalin (uNGAL) in predicting the progression contract associated-acute kidney injury (CA-AKI) to chronic kidney disease (CKD) in planned percutaneous coronary intervention (PCI) patients.Patients and Methods: We examined 387 adult patients who had undergone planned percutaneous coronary intervention (PCI). We determined acute kidney injury (AKI) and chronic kidney disease (CKD) using the criteria set by the Kidney Disease: Improving Global Outcomes (KDIGO). We calculated the estimated glomerular filtration rate (eGFR) using the CKD-EPI formula based on serum creatinine levels. To determine the Vc/eGFR ratio, we considered the contrast medium volume and eGFR for each patient. Additionally, we measured urine NGAL levels using the ELISA method.Results: The percentage of CA-AKI patients who developed CKD after planned PCI was 36.36%. Within the CA-AKI to CKD group, the Vc/eGFR ratio was 2.82, and uNGAL levels were significantly higher at 72.74 ng/mL compared to 1.93 ng/mL for Vc/eGFR ratio and 46.57 ng/mL for uNGAL in the recovery CA-AKI group. This difference was statistically significant (p< 0.001). Diabetic mellitus, urine NGAL concentration, and Vc/eGFR ratio were found to be independent factors in the progression of CA-AKI to CKD. The Vc/eGFR ratio and uNGAL showed predictive capabilities for progressing CA-AKI to CKD with an AUC of 0.884 and 0.878, respectively. The sensitivity was 81.3% for both, while the specificity was 89.3% for Vc/eGFR ratio and 85.7% for uNGAL.Conclusion: The Vc/eGFR ratio and uNGAL were good predictors for CA-AKI to CKD in planned PCI patients.Keywords: planned percutaneous coronary intervention, contract associated-acute kidney injury, CA-AKI progression to CKD, Vc/eGFR ratio, uNGAL

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