Severe Acute Respiratory Infection—Preparedness: Protocol for a Multicenter Prospective Cohort Study of Viral Respiratory Infections

Radu Postelnicu, MD; Avantika Srivastava, MS; Pavan K. Bhatraju, MD, MSc; Mark M. Wurfelc, MD, PhD; George L. Anesi, MD, MSCE, MBE; Martin Gonzalez, MS; Adair Andrews, RN, MATD; Karen Lutrick, PhD; Vishakha K. Kumar, MD, MBA; Timothy M. Uyeki, MD, MPH; Perren J. Cobb, MD; Leopoldo N. Segal, MD; David Brett-Major, MD, MPH; Janice M. Liebler, MD; Christopher J. Kratochvil, MD; Vikramjit Mukherjee, MD; M. Jana Broadhurst, MD, PhD, DTM&H; Richard Lee, MD; David Wyles, MD; Jonathan E. Sevransky, MD, MHS; Laura Evans, MD, MSc; Douglas Landsittel, PhD; the Society of Critical Care Medicine Discovery Network Investigators

doi:10.1097/CCE.0000000000000773

Critical Care Explorations (Oct 2022)

Severe Acute Respiratory Infection—Preparedness: Protocol for a Multicenter Prospective Cohort Study of Viral Respiratory Infections

Radu Postelnicu, MD,
Avantika Srivastava, MS,
Pavan K. Bhatraju, MD, MSc,
Mark M. Wurfelc, MD, PhD,
George L. Anesi, MD, MSCE, MBE,
Martin Gonzalez, MS,
Adair Andrews, RN, MATD,
Karen Lutrick, PhD,
Vishakha K. Kumar, MD, MBA,
Timothy M. Uyeki, MD, MPH,
Perren J. Cobb, MD,
Leopoldo N. Segal, MD,
David Brett-Major, MD, MPH,
Janice M. Liebler, MD,
Christopher J. Kratochvil, MD,
Vikramjit Mukherjee, MD,
M. Jana Broadhurst, MD, PhD, DTM&H,
Richard Lee, MD,
David Wyles, MD,
Jonathan E. Sevransky, MD, MHS,
Laura Evans, MD, MSc,
Douglas Landsittel, PhD,
the Society of Critical Care Medicine Discovery Network Investigators

Affiliations

Radu Postelnicu, MD: 1 Division of Pulmonary, Critical Care, and Sleep Medicine, NYU Grossman School of Medicine, NYU Langone Health, New York, NY.
Avantika Srivastava, MS: 2 Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
Pavan K. Bhatraju, MD, MSc: 3 Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, Seattle, WA.
Mark M. Wurfelc, MD, PhD: 3 Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, Seattle, WA.
George L. Anesi, MD, MSCE, MBE: 4 Division of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Martin Gonzalez, MS: 5 Society of Critical Care Medicine, Mount Prospect, IL.
Adair Andrews, RN, MATD: 5 Society of Critical Care Medicine, Mount Prospect, IL.
Karen Lutrick, PhD: 6 Department of Family and Community Medicine, College of Medicine, University of Arizona, Tucson, AZ.
Vishakha K. Kumar, MD, MBA: 5 Society of Critical Care Medicine, Mount Prospect, IL.
Timothy M. Uyeki, MD, MPH: 7 Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA.
Perren J. Cobb, MD: 8 Departments of Surgery and Anesthesiology, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
Leopoldo N. Segal, MD: 1 Division of Pulmonary, Critical Care, and Sleep Medicine, NYU Grossman School of Medicine, NYU Langone Health, New York, NY.
David Brett-Major, MD, MPH: 9 Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, NE.
Janice M. Liebler, MD: 11 Division of Pulmonary, Critical Care and Sleep Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Christopher J. Kratochvil, MD: 10 Global Center for Health Security, University of Nebraska Medical Center, Omaha, NE.
Vikramjit Mukherjee, MD: 1 Division of Pulmonary, Critical Care, and Sleep Medicine, NYU Grossman School of Medicine, NYU Langone Health, New York, NY.
M. Jana Broadhurst, MD, PhD, DTM&H: 10 Global Center for Health Security, University of Nebraska Medical Center, Omaha, NE.
Richard Lee, MD: 13 Division of Pulmonary Diseases and Critical Care Medicine, University of California, Irvine, CA.
David Wyles, MD: 14 Division of Infectious Diseases, Denver Health Medical Center, Denver, CO.
Jonathan E. Sevransky, MD, MHS: 15 Division of Pulmonary, Allergy, Critical Care and Sleep, School of Medicine, Emory University, Atlanta, GA.
Laura Evans, MD, MSc: 3 Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, Seattle, WA.
Douglas Landsittel, PhD: 17 Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN.
the Society of Critical Care Medicine Discovery Network Investigators

DOI: https://doi.org/10.1097/CCE.0000000000000773
Journal volume & issue: Vol. 4, no. 10
p. e0773

Abstract

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OBJECTIVES:. Respiratory virus infections cause significant morbidity and mortality ranging from mild uncomplicated acute respiratory illness to severe complications, such as acute respiratory distress syndrome, multiple organ failure, and death during epidemics and pandemics. We present a protocol to systematically study patients with severe acute respiratory infection (SARI), including severe acute respiratory syndrome coronavirus 2, due to respiratory viral pathogens to evaluate the natural history, prognostic biomarkers, and characteristics, including hospital stress, associated with clinical outcomes and severity. DESIGN:. Prospective cohort study. SETTING:. Multicenter cohort of patients admitted to an acute care ward or ICU from at least 15 hospitals representing diverse geographic regions across the United States. PATIENTS:. Patients with SARI caused by infection with respiratory viruses that can cause outbreaks, epidemics, and pandemics. INTERVENTIONS:. None. MEASUREMENTS AND MAIN RESULTS:. Measurements include patient demographics, signs, symptoms, and medications; microbiology, imaging, and associated tests; mechanical ventilation, hospital procedures, and other interventions; and clinical outcomes and hospital stress, with specimens collected on days 0, 3, and 7–14 after enrollment and at discharge. The primary outcome measure is the number of consecutive days alive and free of mechanical ventilation (VFD) in the first 30 days after hospital admission. Important secondary outcomes include organ failure-free days before acute kidney injury, shock, hepatic failure, disseminated intravascular coagulation, 28-day mortality, adaptive immunity, as well as immunologic and microbiologic outcomes. CONCLUSIONS:. SARI—Preparedness is a multicenter study under the collaboration of the Society of Critical Care Medicine Discovery, Resilience Intelligence Network, and National Emerging Special Pathogen Training and Education Center, which seeks to improve understanding of prognostic factors associated with worse outcomes and increased resource utilization. This can lead to interventions to mitigate the clinical impact of respiratory virus infections associated with SARI.

Published in Critical Care Explorations

ISSN: 2639-8028 (Online)
Publisher: Wolters Kluwer
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Medical emergencies. Critical care. Intensive care. First aid
Website: https://journals.lww.com/ccejournal/pages/default.aspx

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