Peripherally Acting Opioids in Orofacial Pain

Qing Liu; Qing Liu; Hongwen He; Hongwen He; Lijia Mai; Lijia Mai; Shengyan Yang; Shengyan Yang; Wenguo Fan; Fang Huang; Fang Huang

doi:10.3389/fnins.2021.665445

Frontiers in Neuroscience (May 2021)

Peripherally Acting Opioids in Orofacial Pain

Qing Liu,
Qing Liu,
Hongwen He,
Hongwen He,
Lijia Mai,
Lijia Mai,
Shengyan Yang,
Shengyan Yang,
Wenguo Fan,
Fang Huang,
Fang Huang

Affiliations

Qing Liu: Department of Pediatric Dentistry, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China
Qing Liu: Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China
Hongwen He: Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China
Hongwen He: Department of Oral Anatomy and Physiology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China
Lijia Mai: Department of Pediatric Dentistry, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China
Lijia Mai: Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China
Shengyan Yang: Department of Pediatric Dentistry, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China
Shengyan Yang: Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China
Wenguo Fan: Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China
Fang Huang: Department of Pediatric Dentistry, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China
Fang Huang: Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China

DOI: https://doi.org/10.3389/fnins.2021.665445
Journal volume & issue: Vol. 15

Abstract

Read online

The activation of opioid receptors by exogenous or endogenous opioids can produce significant analgesic effects in peripheral tissues. Numerous researchers have demonstrated the expression of peripheral opioid receptors (PORs) and endogenous opioid peptides (EOPs) in the orofacial region. Growing evidence has shown the involvement of PORs and immune cell-derived EOPs in the modulation of orofacial pain. In this review, we discuss the role of PORs and EOPs in orofacial pain and the possible cellular mechanisms involved. Furthermore, the potential development of therapeutic strategies for orofacial pain is also summarized.

Published in Frontiers in Neuroscience

ISSN: 1662-4548 (Print); 1662-453X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/neuroscience

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Abstract

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