LncRNAs in non-small cell lung cancer: novel diagnostic and prognostic biomarkers

Jiang Fu; Jiang Fu; Li Yu; Li Yu; Hang Yan; Hang Yan; Shengjie Tang; Zixu Wang; Zixu Wang; Tingting Dai; Tingting Dai; Haoyu Chen; Haoyu Chen; Song Zhang; Song Zhang; Haiyang Hu; Haiyang Hu; Tao Liu; Shoujun Tang; Rong He; Haining Zhou; Haining Zhou; Haining Zhou; Haining Zhou

doi:10.3389/fmolb.2023.1297198

Frontiers in Molecular Biosciences (Dec 2023)

LncRNAs in non-small cell lung cancer: novel diagnostic and prognostic biomarkers

Jiang Fu,
Jiang Fu,
Li Yu,
Li Yu,
Hang Yan,
Hang Yan,
Shengjie Tang,
Zixu Wang,
Zixu Wang,
Tingting Dai,
Tingting Dai,
Haoyu Chen,
Haoyu Chen,
Song Zhang,
Song Zhang,
Haiyang Hu,
Haiyang Hu,
Tao Liu,
Shoujun Tang,
Rong He,
Haining Zhou,
Haining Zhou,
Haining Zhou,
Haining Zhou

Affiliations

Jiang Fu: Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China
Jiang Fu: Institute of Surgery, Graduate School, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Li Yu: Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China
Li Yu: Department of Physical Examination, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China
Hang Yan: Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China
Hang Yan: Institute of Surgery, Graduate School, Zunyi Medical University, Zunyi, China
Shengjie Tang: Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China
Zixu Wang: Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China
Zixu Wang: Institute of Surgery, Graduate School, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Tingting Dai: Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China
Tingting Dai: Institute of Surgery, Graduate School, Zunyi Medical University, Zunyi, China
Haoyu Chen: Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China
Haoyu Chen: Institute of Surgery, Graduate School, North Sichuan Medical College, Nanchong, China
Song Zhang: Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China
Song Zhang: Institute of Surgery, Graduate School, North Sichuan Medical College, Nanchong, China
Haiyang Hu: Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China
Haiyang Hu: Institute of Surgery, Graduate School, Zunyi Medical University, Zunyi, China
Tao Liu: Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China
Shoujun Tang: Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China
Rong He: Department of Respiratory and Critical Care Medicine, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China
Haining Zhou: Department of Thoracic Surgery, Suining Central Hospital, An Affiliated Hospital of Chongqing Medical University, Suining, China
Haining Zhou: Institute of Surgery, Graduate School, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Haining Zhou: Institute of Surgery, Graduate School, Zunyi Medical University, Zunyi, China
Haining Zhou: Institute of Surgery, Graduate School, North Sichuan Medical College, Nanchong, China

DOI: https://doi.org/10.3389/fmolb.2023.1297198
Journal volume & issue: Vol. 10

Abstract

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Non-small cell lung cancer (NSCLC) is one of the main causes of cancer-related death worldwide, with a serious impact on human health and life. The identification of NSCLC at an early stage is a formidable task that frequently culminates in a belated diagnosis. LncRNA is a kind of noncoding RNA with limited protein-coding capacity, and its expression is out of balance in many cancers, especially NSCLC. A large number of studies have reported that lncRNA acts a vital role in regulating angiogenesis, invasion, metastasis, and the proliferation and apoptosis of tumor cells, affecting the occurrence and development of NSCLC. Abundant evidence demonstrates that lncRNAs may serve as potential biomarkers for NSCLC diagnosis and prognosis. In this review, we summarize the latest progress in characterizing the functional mechanism of lncRNAs involved in the development of NSCLC and further discuss the role of lncRNAs in NSCLC therapy and chemotherapy resistance. We also discuss the advantages, limitations, and challenges of using lncRNAs as diagnostic or prognostic biomarkers in the management of NSCLC.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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