The applications of patient-derived tumor xenograftmodel in cancer research

Abstract

Establishment of appropriate preclinical research models is important for the tumor transformation research. Although the development of new anti-tumor drugs is emergent, but most of drugs are failed in phaseⅡ clinical trials due to the limitations of preclinical research models. Patient-derived tumor xenograft (PDX) isone of the novel tumor research models established by inoculating patient tumors tissue directly into immunodeficient mice. PDX is a preclinical research model with high clinical predictive value due to its high conservatismof histological and genetic characteristics with donor tumors. Generally, PDX models are widely used in preclinical drug evaluation, biomarker identification and personalized medical treatment. In this review, the methods ofPDX model establishment, the advantages, the applications and the limitations of PDX model in tumor clinical research are summarized. At last, we prospect the future development of PDX model in tumor related research.

Keywords

• pdx model
• tumor research
• clinical prodrug evaluation