Research progress on etiology of gestational diabetes mellitus

Abstract

As a metabolic disorder during pregnancy, gestational diabetes mellitus (GDM) has an important effects on fetal development, neonatal health and maternal long-term health, and is one of the pregnancy complications with high incidence. It is of great significance that we have an accurate understanding of the etiology and risk factors of GDM for its prevention and control. GDM is a complex disease with multiple etiologies. Current studies have shown that the occurrence of GDM may be the result of combined effect of heredity and environment, but the exact etiology is still unclear. In this paper, we summarized the possible etiologies and risk factors of GDM, so as to understand the occurrence and development of GDM better and to provide possible references for prevention and further etiological studies of GDM.

Keywords

• gestational diabetes mellitus
• etiology
• risk factor
• genetic susceptibility
• insulin resistance
• inflammatory cytokines