Advances in understanding Kawasaki disease‐related immuno‐inflammatory response and vascular endothelial dysfunction

Abstract

ABSTRACT Kawasaki disease (KD) is a systemic vasculitis of unknown etiology, which tends to involve coronary arteries and can lead to acquired heart disease in children. The immuno‐inflammatory response and vascular endothelial dysfunction are important causes of coronary artery disease in patients with KD. Multisystem inflammatory syndrome in children (MIS‐C) is a rare inflammatory disease in children identified in recent years, which is caused by severe acute respiratory syndrome coronavirus 2 infection; this disease overlaps with KD. This review examines research progress concerning the immuno‐inflammatory response and vascular endothelial dysfunction associated with KD, as well as differences between KD and MIS‐C.

Keywords

• Kawasaki disease
• Inflammation
• Endothelial cells
• Multisystem inflammatory syndrome in children