Cancer Management and Research (Mar 2019)
The role and diagnostic potential of gastrokine 1 in gastric cancer
Abstract
Olga M Koper-Lenkiewicz, Joanna Kamińska, Beata Gawrońska, Joanna Matowicka-Karna Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Białystok, Poland Introduction: Gene for gastrokine 1 (GKN1) was identified as one of the most significant in gastric cancer and indicated as a potential therapeutic target.Aim: The aim was a review of literature reports concerning the role and diagnostic potential of GKN1 in gastric cancer.Materials and methods: PubMED database was searched for sources using the following keywords: gastrokine 1/GKN1/AMP-18 and gastric cancer, Helicobacter pylori, aspirin, nonsteroidal anti-inflammatory drugs. Preference was given to the sources which were published within the past 10 years.Conclusion: GKN1 is a stomach-specific protein, and its role consists of maintaining mucosal integrity as well as the replenishment of the surface lumen epithelial cells layer. The evaluation of GKN1 expression seems to be a useful indicator of the presence of neoplastic or inflammatory lesions in the gastric mucosa. GKN1 expression is decreased in gastric tumor tissues and derived cell lines and its upregulation in cell lines of gastric cancer induces cells apoptosis. The mechanism by which GKN1 is inactivated in gastric cancer cells is still not fully understood. The future diagnostic capabilities of gastric cancer concern the assessment of serum GKN1 concentration by means of ELISA method. Serum GKN1 concentration is not related to patients’ sex. Moreover, the measurement of GKN1 concentration is possible only after the incubation of samples at 70°C for 10 minutes. Nevertheless, the aspect of quantitative serum GKN1 evaluation is new in the context of available literature and requires further studies. Keywords: gastrokine 1/GKN1, gastric cancer, Helicobacter pylori
