REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis

Abstract

REV-ERBα is a nuclear receptor that links the circadian pathways with those of metabolism. Here the authors show REV-ERBα is also involved with linking the circadian system with the inflammatory pathways of an experimental model of colitis through regulation of the NF-κB/NLRP3 axis.