Short-term blood pressure variability is inversely related to regional amplitude of low frequency fluctuations in older and younger adults

Isabel J. Sible; Hyun Joo Yoo; Jungwon Min; Kaoru Nashiro; Catie Chang; Daniel A. Nation; Mara Mather

Aging Brain (Jan 2023)

Short-term blood pressure variability is inversely related to regional amplitude of low frequency fluctuations in older and younger adults

Isabel J. Sible,
Hyun Joo Yoo,
Jungwon Min,
Kaoru Nashiro,
Catie Chang,
Daniel A. Nation,
Mara Mather

Affiliations

Isabel J. Sible: Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA
Hyun Joo Yoo: Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
Jungwon Min: Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
Kaoru Nashiro: Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
Catie Chang: Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN 37235, USA
Daniel A. Nation: Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA; Department of Psychological Science, University of California Irvine, Irvine, CA 92697, USA
Mara Mather: Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA; Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA; Corresponding author at: University of Southern California, Davis School of Gerontology, 3715 McClintock Ave, Los Angeles, CA 90089, United States.

Journal volume & issue: Vol. 4
p. 100085

Abstract

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Blood pressure variability (BPV), independent of mean blood pressure levels, is associated with cerebrovascular disease burden on MRI and postmortem evaluation. However, less is known about relationships with markers of cerebrovascular dysfunction, such as diminished spontaneous brain activity as measured by the amplitude of low frequency fluctuations (ALFF), especially in brain regions with vascular and neuronal vulnerability in aging. We investigated the relationship between short-term BPV and concurrent regional ALFF from resting state fMRI in a sample of community-dwelling older adults (n = 44) and healthy younger adults (n = 49). In older adults, elevated systolic BPV was associated with lower ALFF in widespread medial temporal regions and the anterior cingulate cortex. Higher systolic BPV in younger adults was also related to lower ALFF in the medial temporal lobe, albeit in fewer subregions, and the amygdala. There were no significant associations between systolic BPV and ALFF across the right/left whole brain or in the insular cortex in either group. Findings suggest a possible regional vulnerability to cerebrovascular dysfunction and short-term fluctuations in blood pressure. BPV may be an understudied risk factor for cerebrovascular changes in aging.

Published in Aging Brain

ISSN: 2589-9589 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/aging-brain

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