Nature Communications (Jan 2022)
Robust and durable serological response following pediatric SARS-CoV-2 infection
- Hanna Renk,
- Alex Dulovic,
- Alina Seidel,
- Matthias Becker,
- Dorit Fabricius,
- Maria Zernickel,
- Daniel Junker,
- Rüdiger Groß,
- Janis Müller,
- Alexander Hilger,
- Sebastian F. N. Bode,
- Linus Fritsch,
- Pauline Frieh,
- Anneke Haddad,
- Tessa Görne,
- Jonathan Remppis,
- Tina Ganzemueller,
- Andrea Dietz,
- Daniela Huzly,
- Hartmut Hengel,
- Klaus Kaier,
- Susanne Weber,
- Eva-Maria Jacobsen,
- Philipp D. Kaiser,
- Bjoern Traenkle,
- Ulrich Rothbauer,
- Maximilian Stich,
- Burkhard Tönshoff,
- Georg F. Hoffmann,
- Barbara Müller,
- Carolin Ludwig,
- Bernd Jahrsdörfer,
- Hubert Schrezenmeier,
- Andreas Peter,
- Sebastian Hörber,
- Thomas Iftner,
- Jan Münch,
- Thomas Stamminger,
- Hans-Jürgen Groß,
- Martin Wolkewitz,
- Corinna Engel,
- Weimin Liu,
- Marta Rizzi,
- Beatrice H. Hahn,
- Philipp Henneke,
- Axel R. Franz,
- Klaus-Michael Debatin,
- Nicole Schneiderhan-Marra,
- Ales Janda,
- Roland Elling
Affiliations
- Hanna Renk
- University Children’s Hospital Tübingen
- Alex Dulovic
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Alina Seidel
- Institute of Molecular Virology, Ulm University Medical Center
- Matthias Becker
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Dorit Fabricius
- Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University
- Maria Zernickel
- Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University
- Daniel Junker
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Rüdiger Groß
- Institute of Molecular Virology, Ulm University Medical Center
- Janis Müller
- Institute of Molecular Virology, Ulm University Medical Center
- Alexander Hilger
- Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg
- Sebastian F. N. Bode
- Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University
- Linus Fritsch
- Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg
- Pauline Frieh
- Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg
- Anneke Haddad
- Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg
- Tessa Görne
- Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg
- Jonathan Remppis
- University Children’s Hospital Tübingen
- Tina Ganzemueller
- Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen
- Andrea Dietz
- Institute of Virology, Ulm University Medical Center
- Daniela Huzly
- Institute of Virology, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg
- Hartmut Hengel
- Institute of Virology, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg
- Klaus Kaier
- Institute of Medical Biometry and Statistics, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg
- Susanne Weber
- Institute of Medical Biometry and Statistics, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg
- Eva-Maria Jacobsen
- Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University
- Philipp D. Kaiser
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Bjoern Traenkle
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Ulrich Rothbauer
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Maximilian Stich
- Department of Pediatrics I, University Children’s Hospital Heidelberg
- Burkhard Tönshoff
- Department of Pediatrics I, University Children’s Hospital Heidelberg
- Georg F. Hoffmann
- Department of Pediatrics I, University Children’s Hospital Heidelberg
- Barbara Müller
- Department of Infectious Diseases, Virology, Heidelberg University Hospital
- Carolin Ludwig
- Institute of Transfusion Medicine, Ulm University
- Bernd Jahrsdörfer
- Institute of Transfusion Medicine, Ulm University
- Hubert Schrezenmeier
- Institute of Transfusion Medicine, Ulm University
- Andreas Peter
- Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tübingen
- Sebastian Hörber
- Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tübingen
- Thomas Iftner
- Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen
- Jan Münch
- Institute of Molecular Virology, Ulm University Medical Center
- Thomas Stamminger
- Institute of Virology, Ulm University Medical Center
- Hans-Jürgen Groß
- Institute of Clinical Chemistry, Ulm University
- Martin Wolkewitz
- Institute of Medical Biometry and Statistics, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg
- Corinna Engel
- University Children’s Hospital Tübingen
- Weimin Liu
- Department of Microbiology and Department of Medicine, University of Pennsylvania
- Marta Rizzi
- Department of Rheumatology and Clinical Immunology, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg
- Beatrice H. Hahn
- Department of Microbiology and Department of Medicine, University of Pennsylvania
- Philipp Henneke
- Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg
- Axel R. Franz
- University Children’s Hospital Tübingen
- Klaus-Michael Debatin
- Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University
- Nicole Schneiderhan-Marra
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Ales Janda
- Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University
- Roland Elling
- Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg
- DOI
- https://doi.org/10.1038/s41467-021-27595-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
In this prospective cohort study, authors follow 328 households in Germany with at least one confirmed SARS-CoV-2 infection and find that children are more likely to seroconvert without symptoms and have higher specific antibody levels that persist longer than in adults.
