Functions of p120-catenin in physiology and diseases

Xin Jin; Ting Lin; Yunjuan Wang; Xiaoqian Li; Yanhong Yang

doi:10.3389/fmolb.2024.1486576

Frontiers in Molecular Biosciences (Oct 2024)

Functions of p120-catenin in physiology and diseases

Xin Jin,
Ting Lin,
Yunjuan Wang,
Xiaoqian Li,
Yanhong Yang

Affiliations

Xin Jin: The First Affiliated Hospital (The First School of Clinical Medicine), Guangdong Pharmaceutical University, Guangzhou, China
Ting Lin: Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China
Yunjuan Wang: The First Affiliated Hospital (The First School of Clinical Medicine), Guangdong Pharmaceutical University, Guangzhou, China
Xiaoqian Li: Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China
Yanhong Yang: The First Affiliated Hospital (The First School of Clinical Medicine), Guangdong Pharmaceutical University, Guangzhou, China

DOI: https://doi.org/10.3389/fmolb.2024.1486576
Journal volume & issue: Vol. 11

Abstract

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p120-catenin (p120) plays a vital role in regulating cell-cell adhesion at adherens junctions, interacting with the juxtamembrane domain (JMD) core region of E-cadherin and regulates the stability of cadherin at the cell surface. Previous studies have shown significant functions of p120 in cell-cell adhesion, tumor progression and inflammation. In this review, we will discuss recent progress of p120 in physiological processes and diseases, and focus on the functions of p120 in the regulation of cancer and inflammation.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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Abstract

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