Nature Communications (Aug 2022)
Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals
- Qin Qin Huang,
- Neneh Sallah,
- Diana Dunca,
- Bhavi Trivedi,
- Karen A. Hunt,
- Sam Hodgson,
- Samuel A. Lambert,
- Elena Arciero,
- John Wright,
- Chris Griffiths,
- Richard C. Trembath,
- Harry Hemingway,
- Michael Inouye,
- Sarah Finer,
- David A. van Heel,
- R. Thomas Lumbers,
- Hilary C. Martin,
- Karoline Kuchenbaecker
Affiliations
- Qin Qin Huang
- Department of Human Genetics, Wellcome Sanger Institute
- Neneh Sallah
- Institute of Health Informatics, University College London
- Diana Dunca
- Institute of Health Informatics, University College London
- Bhavi Trivedi
- Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Karen A. Hunt
- Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Sam Hodgson
- Primary Care Research Centre, University of Southampton
- Samuel A. Lambert
- Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge
- Elena Arciero
- Department of Human Genetics, Wellcome Sanger Institute
- John Wright
- Bradford Institute for Health Research, Bradford Teaching Hospitals National Health Service (NHS) Foundation Trust
- Chris Griffiths
- Institute of Population Health Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Richard C. Trembath
- Department of Medical and Molecular Genetics, King’s College London
- Harry Hemingway
- Institute of Health Informatics, University College London
- Michael Inouye
- Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge
- Sarah Finer
- Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- David A. van Heel
- Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- R. Thomas Lumbers
- Institute of Health Informatics, University College London
- Hilary C. Martin
- Department of Human Genetics, Wellcome Sanger Institute
- Karoline Kuchenbaecker
- UCL Genetics Institute, University College London
- DOI
- https://doi.org/10.1038/s41467-022-32095-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Most genetic studies of disease have been done in European ancestry cohorts, and the relevance to other populations is not guaranteed. Here, the authors use data from 22,000 British South Asian individuals and find that the transferability of polygenic scores was high for lipids and blood pressure, and lower for BMI and coronary artery disease.
