Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities

Singamsetty Radha Krishna; Mandava Venkata Naga Brahmeshwar Rao; Tirmalaraju Satyanaryana Raju; Vurimidi Himabindu; Ghanta Mahesh Reddy

doi:10.1155/2008/308724

E-Journal of Chemistry (Jan 2008)

Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities

Singamsetty Radha Krishna,
Mandava Venkata Naga Brahmeshwar Rao,
Tirmalaraju Satyanaryana Raju,
Vurimidi Himabindu,
Ghanta Mahesh Reddy

Affiliations

Singamsetty Radha Krishna: Research and Development, Dr. Reddy's Laboratories Ltd., Integrated Product and Development, Unit-III, Plot No. 116, S V Co-Op. Ind. Estate, Bollaram, Jinnaram, Medak Dist 502 325; A P, India
Mandava Venkata Naga Brahmeshwar Rao: Research and Development, Dr. Reddy's Laboratories Ltd., Integrated Product and Development, Unit-III, Plot No. 116, S V Co-Op. Ind. Estate, Bollaram, Jinnaram, Medak Dist 502 325; A P, India
Tirmalaraju Satyanaryana Raju: Research and Development, Dr. Reddy's Laboratories Ltd., Integrated Product and Development, Unit-III, Plot No. 116, S V Co-Op. Ind. Estate, Bollaram, Jinnaram, Medak Dist 502 325; A P, India
Vurimidi Himabindu: Institute of Sciences and Technology, Center for Environmental Sciences, J.N.T. University, Kukatpally, Hyderabad-500072, India
Ghanta Mahesh Reddy: Research and Development, Dr. Reddy's Laboratories Ltd., Integrated Product and Development, Unit-III, Plot No. 116, S V Co-Op. Ind. Estate, Bollaram, Jinnaram, Medak Dist 502 325; A P, India

DOI: https://doi.org/10.1155/2008/308724
Journal volume & issue: Vol. 5, no. 3
pp. 562 – 566

Abstract

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Three unknown impurities in rosiglitazone maleate 1 bulk drug at level below 0.1% (ranging from 0.05 to 0.1%) were detected by simple reverse phase high performance liquid chromatography. These impurities were preliminarily identified with LC-MS and characterized by the mass number of the impurities. Different experiments were conducted and finally synthesized and characterized the unknown impurities.

Published in E-Journal of Chemistry

ISSN: 0973-4945 (Print); 2090-9810 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://onlinelibrary.wiley.com/journal/2962

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