A Multifunctional Nanocatalytic Metal-Organic Framework as a Ferroptosis Amplifier for Mild Hyperthermia Photothermal Therapy
Ying Deng,
Duo Wang,
Wenhua Zhao,
Guanhua Qiu,
Xiaoqi Zhu,
Qin Wang,
Tian Qin,
Jiali Tang,
Jinghang Jiang,
Ningjing Lin,
Lili Wei,
Yichen Liu,
Yuan Xie,
Jie Chen,
Liu Deng,
Junjie Liu
Affiliations
Ying Deng
Department of Medical Ultrasound, Guangxi Medical University Cancer Hospital,
Guangxi Medical University, Nanning, Guangxi, China.
Duo Wang
Department of Medical Ultrasound, Guangxi Medical University Cancer Hospital,
Guangxi Medical University, Nanning, Guangxi, China.
Wenhua Zhao
Department of Oncology and Research Department, Guangxi Medical University Cancer Hospital,
Guangxi Medical University, Nanning, Guangxi, China.
Guanhua Qiu
Department of Medical Ultrasound, Guangxi Medical University Cancer Hospital,
Guangxi Medical University, Nanning, Guangxi, China.
Xiaoqi Zhu
Department of Medical Ultrasound, Guangxi Medical University Cancer Hospital,
Guangxi Medical University, Nanning, Guangxi, China.
Qin Wang
Department of Medical Ultrasound, Guangxi Medical University Cancer Hospital,
Guangxi Medical University, Nanning, Guangxi, China.
Tian Qin
Department of Medical Ultrasound, Guangxi Medical University Cancer Hospital,
Guangxi Medical University, Nanning, Guangxi, China.
Jiali Tang
Department of Medical Ultrasound, Guangxi Medical University Cancer Hospital,
Guangxi Medical University, Nanning, Guangxi, China.
Jinghang Jiang
Department of Medical Ultrasound, Guangxi Medical University Cancer Hospital,
Guangxi Medical University, Nanning, Guangxi, China.
Ningjing Lin
Department of Medical Ultrasound, Guangxi Medical University Cancer Hospital,
Guangxi Medical University, Nanning, Guangxi, China.
Lili Wei
Department of Medical Ultrasound, Guangxi Medical University Cancer Hospital,
Guangxi Medical University, Nanning, Guangxi, China.
Yichen Liu
Department of Medical Ultrasound, Guangxi Medical University Cancer Hospital,
Guangxi Medical University, Nanning, Guangxi, China.
Yuan Xie
Department of Oncology and Research Department, Guangxi Medical University Cancer Hospital,
Guangxi Medical University, Nanning, Guangxi, China.
Jie Chen
Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital,
Guangxi Medical University, Nanning, Guangxi, China.
Liu Deng
Hunan Provincial Key Laboratory of Micro and Nano Materials Interface Science, College of Chemistry and Chemical Engineering,
Central South University, Changsha, Hunan, China.
Junjie Liu
Department of Medical Ultrasound, Guangxi Medical University Cancer Hospital,
Guangxi Medical University, Nanning, Guangxi, China.
Hyperthermia therapy is considered an effective anticancer strategy. However, high temperature can trigger an excessive inflammatory response, leading to tumor self-protection, immunosuppression, metastasis, and recurrence. To address this issue, we reported a multifunctional photothermal nanoplatform to achieve mild hyperthermia photothermal therapy (mild PTT) based on cisplatin (DDP) and a ferrocene metal-organic framework (MOF-Fc) nanocomposite, which can specifically enhance ferroptosis-triggered oxidative stress levels and synchronously amplify mild hyperthermia PTT-mediated anticancer responses. Both in vitro and in vivo antineoplastic results verify the superiority of mild PTT with DDP/MOF-Fc@HA. The combination of DDP and MOF-Fc exhibits Fenton catalytic activity and glutathione depletion capacity, magnifying mild hyperthermia effects via the radical oxygen species (ROS)-adenosine triphosphate (ATP)-HSP silencing pathway, with important implications for clinical hyperthermia therapy.
