Journal of Veterinary Internal Medicine (Sep 2020)

Colorectal basidiobolomycosis in a dog

  • Margaux Marclay,
  • Ingeborg M. Langohr,
  • Frederic P. Gaschen,
  • Aline Rodrigues‐Hoffmann,
  • Mariano Carossino,
  • Mathew A. Stewart,
  • Alexandra N. Myers,
  • Amy M. Grooters

DOI
https://doi.org/10.1111/jvim.15859
Journal volume & issue
Vol. 34, no. 5
pp. 2091 – 2095

Abstract

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Abstract A 7‐year‐old castrated male French Bulldog was examined for chronic large intestinal enteropathy. A colonic mass and thickened rectal mucosa were identified, and histopathologic examination of endoscopic biopsy specimens disclosed eosinophilic proctitis with large (5‐20 μm), irregularly shaped, pauciseptate hyphae that were Gomori methenamine silver and periodic acid‐Schiff positive. Amplification and sequencing of ribosomal DNA extracted from paraffin‐embedded tissues yielded a sequence with 97% identity to GenBank sequences for Basidiobolus ranarum. After itraconazole, terbinafine, and prednisone administration, clinical signs resolved rapidly, and sonographic lesions were largely absent after 6 weeks. Treatment was discontinued by the owner 15 weeks after diagnosis. Three weeks later, the dog collapsed acutely and was euthanized. Necropsy identified metastatic islet cell carcinoma and grossly unremarkable colorectal tissues. However, histopathology of the rectum disclosed multifocal submucosal granulomas with intralesional hyphae morphologically similar to those previously observed. This report is the first to describe medical treatment of gastrointestinal basidiobolomycosis in a dog.

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