Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

Yasuhito Yahara; Hiroshi Takemori; Minoru Okada; Azuma Kosai; Akihiro Yamashita; Tomohito Kobayashi; Kaori Fujita; Yumi Itoh; Masahiro Nakamura; Hiroyuki Fuchino; Nobuo Kawahara; Naoshi Fukui; Akira Watanabe; Tomoatsu Kimura; Noriyuki Tsumaki

doi:10.1038/ncomms10959

Nature Communications (Mar 2016)

Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

Yasuhito Yahara,
Hiroshi Takemori,
Minoru Okada,
Azuma Kosai,
Akihiro Yamashita,
Tomohito Kobayashi,
Kaori Fujita,
Yumi Itoh,
Masahiro Nakamura,
Hiroyuki Fuchino,
Nobuo Kawahara,
Naoshi Fukui,
Akira Watanabe,
Tomoatsu Kimura,
Noriyuki Tsumaki

Affiliations

Yasuhito Yahara: Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University
Hiroshi Takemori: Laboratory of Cell Signaling and Metabolic Disease, National Institutes of Biomedical Innovation, Health and Nutrition
Minoru Okada: Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University
Azuma Kosai: Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University
Akihiro Yamashita: Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University
Tomohito Kobayashi: Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University
Kaori Fujita: Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University
Yumi Itoh: Laboratory of Cell Signaling and Metabolic Disease, National Institutes of Biomedical Innovation, Health and Nutrition
Masahiro Nakamura: Genome/Epigenome Analysis Core Facility, Center for iPS Cell Research and Application, Kyoto University
Hiroyuki Fuchino: Tsukuba Division, Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition
Nobuo Kawahara: Tsukuba Division, Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition
Naoshi Fukui: Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
Akira Watanabe: Genome/Epigenome Analysis Core Facility, Center for iPS Cell Research and Application, Kyoto University
Tomoatsu Kimura: Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama
Noriyuki Tsumaki: Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University

DOI: https://doi.org/10.1038/ncomms10959
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Therapies are needed for the prevention of chondrocyte hypertrophy and thinning of articular cartilage, features of osteoarthritic joint destruction. Here, the authors show that interfering with Sik3 signalling can increase the size of the chondrocyte population and reduce severity of a surgically induced mouse model of osteoarthritis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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